![]() ![]() ![]() Uni- or bilateral punctate DWI lesions can be detected in the hippocampus 24–72 hours after the initial symptoms in up to three quarters of TGA patients. Diffusion-weighted magnetic resonance imaging (DWI) can support a diagnosis of TGA and rule out other causes of amnesia, for example certain types of ischaemic stroke. The diagnosis of TGA is based on the clinical criteria set out by Hodges and Warlow. Although the underlying pathophysiology still remains an enigma, we know from experience that physical or emotional stress are possible triggers. Patients demonstrate no other neurological or cognitive deficits, there is no loss of personal identity, previously acquired skills are not impaired, and characteristically they seem to realise that something is amiss and keep asking the same questions. Transient global amnesia (TGA) is an idiopathic entity with a complete loss of memory acquisition that resolves within a few hours. Prospective studies will have to ascertain whether measuring troponin in suspected TGA will be helpful and improve outcome. ![]() To avoid a delay in stroke diagnosis – because DWI in TGA is usually deferred by a day or two – results from one large retrospective case series indicate that acutely elevated cardiac troponin levels will preselect those at highest risk of stroke as a TGA mimic and so are in need of urgent imaging and also cardiological work-up. Retrospective case series with diffusion-weighted magnetic resonance imaging (DWI) demonstrated that on average 5.4% of putative TGA cases are actually mimicked by strokes. Transient global amnesia (TGA) is a well-defined syndrome with temporarily impaired memory formation lasting several hours. ![]()
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